摘要
通过3,3′-((乙烷-1,2-二基双(2-甲基吡啶杂氮二基)双(亚甲基))双(2-羟基-5-甲基苯甲醛)与2-羟基-1,3-丙二胺的缩合反应得到一种具有双吡啶悬臂的双核锰配合物。通过X射线单晶衍射确定了该配合物结构,结果显示其分子式为[Mn_(2)(C_(37)H_(43)N_(6)O_(6))]·(ClO_(4))_(2)。该配合物属于单斜晶系,P21/c空间群,晶胞参数为:a=1.09650(19)nm,b=1.4195(3)nm,c=3.1094(5)nm,β=108.153(5)°。进一步分析表明两个二价锰离子分别与(N_(amine))2(N_(imine))_(2)O_(3)和(N_(imine))_(2)O_(4)体系配位,它们与配位原子形成的几何构型分别是十面体和扭曲的八面体。两个中心锰离子距离为0.3316 nm,由酚氧原子和醋酸根共同桥联。另外,本文也利用伏安法和黏度法对该配合物与小牛胸腺DNA的结合能力进行研究,实验结果表明它们之间的结合方式为弱的插入作用。
A new dinuclear manganese(Ⅱ)complex with bis-pyridine pendant-arms was synthesized by condensation between 3,3′-((ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))bis(methylene))bis(2-hydroxy-5-methylbenzaldehyde)and 2-hydroxy-1,3-diaminopropane in the presence of manganese(Ⅱ).The complex was determined by X-ray diffraction single crystal structure analysis,and the corresponding formula is[Mn_(2)(C_(37)H_(43)N_(6)O_(6))]·(ClO_(4))_(2).The results indicate that the complex crystallizes in monoclinic,space group P21/c,with a=1.09650(19)nm,b=1.4195(3)nm,c=3.1094(5)nm,β=108.153(5)°.The crystal structure shows that the two manganese(Ⅱ)ions in the phenolbased macrocyclic dinuclear complex are coordinated with(N_(amine))2(N_(imine))_(2)O_(3)and(N_(imine))_(2)O_(4)sites,the corresponding geometry around each manganese(Ⅱ)center are decahedron and distorted octahedron.Two manganese(Ⅱ)centers are equivalently bridged by the phenolic oxygens and an acetate radical with the intermetallic separation of 0.3316 nm.Moreover,the binding ability of the complex toward calf thymus DNA were analyzed by voltammetric and viscosity method,which indicate the bonding mode between them is weak intercalation.
作者
王洋
李铭
吴宇
闫俊涛
毛佳伟
WANG Yang;LI Ming;WU Yu;YAN Juntao;MAO Jiawei(School of Chemical and Environmental Engineering,Wuhan Polytechnic University,Wuhan 430023,China;Sichuan Institute of Product Quality Supervision and Inspection,Chengdu 610100,China)
出处
《人工晶体学报》
CAS
北大核心
2022年第7期1220-1226,共7页
Journal of Synthetic Crystals
基金
Key Research and Development Project of Hubei Province(2020BBB068)
Nature Science Foundation of Hubei Province(2020CFB400)。
关键词
双核锰配合物
大环金属配合物
晶体结构
DNA结合能力
dinuclear manganese(Ⅱ)complex
macrocyclic metal complex
crystal structure
DNA binding ability
