摘要
目的:探讨拉莫三嗪联合奥卡西平在成人局灶性癫痫发作患者中的应用效果.方法:采用前瞻性随机试验方法,选择2019年1月-2020年3月河南省商丘市立医院收治的76例局灶性癫痫患者,采用抽签法分为两组,各38例.对照组给予奥卡西平进行治疗,观察组加用拉莫三嗪进行治疗,两组连续治疗4个月.观察两组患者治疗4个月后的临床疗效,治疗前、治疗4个月后的血清指标水平、认知功能及治疗期间不良反应发生情况.结果:治疗4个月,与对照组(63.16%)相比,观察组治疗总有效率(86.84%)更高(P<0.05);治疗4个月后,与治疗前相比,两组的血清脑源性神经营养因子(BDNF)、胶质细胞原纤维酸性蛋白(GFAP)及神经元特异性烯醇化酶(NSE)水平均显著降低,其中观察组降低更为显著(P<0.05);治疗4个月后,与治疗前相比,两组患者简易精神状态检查量表(MMSE)评分均显著升高,其中观察组升高更为显著(P<0.05);治疗期间,观察组患者不良反应发生率(15.79%)与对照组(13.16%)相差不多(P>0.05).结论:拉莫三嗪与奥卡西平联合使用可有效改善成人局灶性癫痫发作患者神经功能,提高患者认知能力,且不良反应轻微,值得推广.
Objective:To investigate the efficacy of lamotrigine combined with oxazepine in adult patients with focal epilepsy.Methods:A prospective randomized trial was used to select 76 patients with focal epilepsy admitted to Shangqiu Municipal Hospital of Henan Province from January 2019 to March 2020,and they were divided into two groups by lottery,with 38 patients in each group.The control group was treated with oxazepine,the observation group was treated with lamotrigine,and the two groups were treated for 4 months.The clinical efficacy,serum index levels,cognitive function and the occurrence of adverse reactions during treatment were observed in 2 groups after 4 months of treatment.Results:After 4 months of treatment,the total effective rate of observation group(86.84%)was higher than that of control group(63.16%)(P<0.05).After 4 months of treatment,compared with before treatment,the levels of serum brain-derived neurotrophic factor(BDNF),glial fibrillary acidic protein(GFAP)and neuron specific enolase(NSE)in 2 groups were significantly decreased,especially in the observation group(P<0.05).After 4 months of treatment,compared with before treatment,MMSE scores in 2 groups were significantly increased,and the increase in observation group was more significant(P<0.05).During treatment,the incidence of adverse reactions in observation group(15.79%)was similar to that in control group(13.16%)(P>0.05).Con clusi on:Lamotrigine combined with oxazepine can effectively improve the neurological function and cognitive ability of adult patients with focal epilepsy,and the adverse reactions are mild,which is worthy of promotion.
作者
朱艳丽
曹冬凌
郭宝宁
Zhu Yan-li;Cao Dong-ling;Guo Bao-ning(Department of Neurology,Shangqiu Municipal Hospital,Shangqiu 476100,Henan,China)
出处
《四川生理科学杂志》
2021年第8期1456-1459,共4页
Sichuan Journal of Physiological Sciences
