摘要
目的分析血栓通对非动脉炎性前部缺血性视神经病变(AION)患者视力、视野改善效果及其作用机制。方法选取我院2014年9月—2017年3月收治的78例(81眼)非动脉炎性AION患者,以随机数表法分为观察组(39例,40眼)和对照组(39例,41眼)。二组均给予激素治疗,对照组肌肉注射注射用鼠神经生长因子、穴位注射复方樟柳碱注射液以及口服甲钴胺片,观察组在对照组治疗基础上静脉滴注血栓通注射液,均连续治疗4周。评定临床疗效,并评估视力、视野改善效果。结果观察组临床治疗总有效率为92.31%,明显高于对照组(74.36%)(P<0.05)。与对照组比较,观察组视盘水肿改善程度明显高,且视盘水肿完全吸收时间明显缩短(P<0.05)。二组治疗前视力均以<0.5为主,且视力状况比较差异无统计学意义(P>0.05),治疗后二组视力均显著改善,观察组视力以≥0.8为主,对照组以≥0.5为主,观察组视力改善效果显著优于对照组(P<0.05)。二组治疗前平均光敏度、平均视野缺损比较差异无统计学意义(P>0.05),治疗后平均光敏度、平均视野缺损均显著改善,与治疗前比较差异有统计学意义(P<0.05),且与对照组比较,治疗后观察组视野平均光敏度显著提高,平均视野缺损显著减小(P<0.05)。结论血栓通辅助治疗非动脉炎性AION可有效改善患者视觉通路、视盘水肿,改善视野和提高视力,从而有效防治视神经萎缩,改善生活质量。
Objective To analyze the improvement effect of Xueshuantong injection on visual acuity and visual field in patients with non-arterial anterior ischemic optic neuropathy（AION）and its mechanism.MethodsTotally 78 cases of non-arterial AION patients（81 eyes）were selected in author＇s hospital from September2014 to March2017 and divided into the experimental group（39 cases,40 eyes）and the control group（39 cases,41 eyes）according to the random number table method.The two groups were given hormone therapy,and the control group was given intramuscular injection of rat nerve growth factor,acupoint injection of compound Anisodine injection and oral Mecobalamin tablets,and the experimental group was given intravenous injection of Xueshuantong injection on the basis of treatment in the control group.The two groups were given continuous treatment for 4 weeks.The clinical efficacy was evaluated and the improvements of visual acuity and visual field were evaluated.Results The total effective rate of clinical treatment was 92.31% in the experimental group,which was significantly higher than that in the control group with 74.36%（P〈0.05）.Compared with the control group,the improvement of optic disc edema in the experimental group was significantly higher,and the total absorption time of the optic disc edema was significantly shortened（P〈0.05）.The visual acuity of the two groups was mainly〈0.5 before treatment,and there was no significant difference in visual acuity between the two groups（P〉0.05）.The visual acuity of the two groups was significantly improved after treatment,and the visual acuity was≥0.8 in the experimental group and ≥0.5 in the control group,and the improvement of visual acuity in the experimental groups was significantly better than that in the control group（P〈0.05）.There was no significant difference in the average light sensitivity and mean visual field defect between the two groups before treatment（P〉0.05）,and the average light sensitivity and mean visual fie
作者
关怀英
孔凡宏
张大卫
吴胜卫
Guan Huaiying;Kong Fanhong;Zhang Dawei;et al.(Beijing Luhe Hospital, Capital Medical University, Beij ing 101149, China)
出处
《中国煤炭工业医学杂志》
2018年第1期6-10,共5页
Chinese Journal of Coal Industry Medicine
基金
北京市优秀人才培养资助项目(编号:2013D008011000001)
关键词
血栓通
非动脉炎性前部缺血性视神经病变
视野
视力
Xueshuantong injection
Non-arterial inflammatory
AION
Visual field
Visual acuity
