摘要
目的:通过meta分析评价miRNA-146a rs2910164位点基因多态性与肝癌易感性之间的相关性。方法:系统地检索Pub Med、Embase、Web of Science、中国知网以及中国生物医学文献数据库2017年1月30日之前发表的相关文章,用总的比值比(odd ratios,OR)及相应的95%可信区间(credibility intervals,CI)来评价miRNA-146a基因多态性与肝癌易感性之间的相关性。结果:共纳入了18项病例对照研究,包括5 657例肝癌病例与6 680例健康对照。经过统计分析未发现miRNA-146a rs2910164位点的基因多态性与肝癌易感性之间存在相关性(C vs.G:OR=0.96,95%CI=0.88~1.06;GC vs.GG:OR=0.98,95%CI=0.88~1.09;CC vs.GG:OR=0.90,95%CI=0.74~1.09;GC/CC vs.GG:OR=0.95,95%CI=0.82~1.10;CC vs.GC/GG:OR=0.95,95%CI=0.84~1.07)。结论:目前没有足够证据能够证明miRNA-146a基因多态性与肝癌易感性之间存在相关性。未来有必要在大规模和设计完善的研究中加以验证。
Objective：To assess the association between miRNA-146 a rs2910164 polymorphism and HCC risk by a meta-analysis.Methods：A systematical search of studies was conducted in papers published in Pub Med,Embase,Web of Science,China National Knowledge Infrastructure （CNKI） and Chinese Biomedical Literature Database （CBM） databases before January 30,2017.Odds ratios （OR） and 95% confidence intervals （95% CI） were used to evaluate the association between miRNA-146 a polymorphism and HCC risk.Results：A total of 18 case-control studies involving 5 657 cases and 6 680 healthy controls were included in this meta-analysis,in which no association was found between miRNA-146 a rs2910164 polymorphism and HCC risk in any genetic models （C versus G：OR=0.96,95% CI =0.88 ~1.06;GC versus GG：OR =0.98,95% CI =0.88 ~1.09;CC versus GG：OR =0.90,95% CI =0.74 ~1.09;GC/CC versus GG：OR=0.95,95%CI=0.82~1.10;CC versus GC/GG：OR=0.95,95%CI=0.84~1.07）.Conclusion： No sufficient evidence supports the association between miRNA-146 a rs2910164 polymorphism with hepatocellular cacinoma risk.The conclusion should be verified in large-scale and well-designed studies in the future.
出处
《南京医科大学学报（自然科学版）》
CSCD
北大核心
2017年第9期1222-1226,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家自然科学基金(81301823)
