摘要
目的:探讨胃蛋白酶原(PGⅠ、PGⅠ/PGⅡ)联合糖类抗原CA199、糖蛋白抗原CA125、糖脂类抗原CA242、糖类抗原CA724、癌胚抗原CEA检测在胃癌早期诊断中的价值。方法:检测80例胃癌患者血清(均经胃镜取材,病理活检确诊)、60例胃良性病变患者血清(经胃镜确诊的浅表性胃炎、萎缩性胃炎、胃十二指肠溃疡等)、100例健康人群血清(作为正常对照组),比较三组间的数值变化以及单一检测和联合检测敏感度、特异度的差异。结果:胃癌组和胃良性病变组及健康对照组之间,肿瘤标志物PGⅠ、PGⅠ/PGⅡ和CA199、CA125、CA724、CA242及CEA检测水平均有统计学差异(P<0.05)。较各单一指标检测,胃蛋白酶原及多肿瘤标志物联合检测敏感度为85.6%,明显增高,差异均有统计学意义(P<0.05)。结论:肿瘤标志物PGⅠ、PGⅠ/PGⅡ比值、CA199、CA125、CA724、CA242及CEA单一检测对胃癌的诊断均有一定价值,7者联合检测更能提高胃癌早期的诊断率。
Objective：To explore the value of pepsinogen（PGⅠ,PGⅠ/PGⅡ） combined with carbohydrate antigen CA199,glycoprotein antigen CA125,glycolipid antigen CA242,carbohydrate antigen CA724,carcinoembryonic antigen CEA in early diagnosis of gastric cancer.Methods：The serum of 80 cases of gastric cancer patients（all confirmed by gastroscopy,pathological biopsy）,60 cases of benign gastric lesions（superficial gastritis,atrophic gastritis,gastroduodenal ulcer,etc,confirmed by gastroscopy）,100 cases of health persons（as a normal control group） were used to compared the numerical changes in the three groups and the differences in sensitivity and specificity between single detection and combined detection.Results：There were statistically significant differences in the level of tumor markers PGⅠ,PGⅠ/PGⅡ and CA199,CA125,CA724,CA242 and CEA levels in the three groups（P〈0.05）.Compared with the single index detection,the sensitivity of combined detection was 85.6%,the differences were statistically significant（P〈0.05）.Conclusion：The single detection of PGⅠ,PGⅠ/PGⅡ ratio,CA199,CA125,CA724,CA242 and CEA for the diagnosis of gastric cancer have a certain value,and and the combined detection of above seven tumor makers could improve the early diagnosis rate of gastric cancer.
出处
《现代肿瘤医学》
CAS
2017年第16期2622-2625,共4页
Journal of Modern Oncology
