摘要
目的：分析食物不耐受患几临床症状及食物不耐受情况，为儿童食物不耐受的诊治提供临床依据。方法：采用酶联免疫吸附法，对门诊333例药物治疗效果欠佳、高度怀疑为食物不耐受相关表现的儿童进行14种食物（牛肉、鸡肉、鳕鱼、玉米、蟹、鸡蛋、蘑菇、牛奶、猪肉、大米、虾、大豆、西红柿、小麦）特异性IgG抗体检测，分析不同年龄患儿的食物不耐受情况。结果：333例疑诊为食物不耐受患儿中312例食物特异性IgG抗体水平检测结果为阳性。患儿表现为呼吸道症状105例、消化道症状53例、皮肤症状42例、神经系统症状29例、营养不良26例、心前区不适22例、泌尿系统症状11例，其他症状24例；14种食物的不耐受阳性率居前4位的是：鸡蛋、牛奶、大豆、西红柿；≤1岁组患儿牛奶不耐受阳性率最高（79．0％），4～18岁组最低（63．0％），两组比较差异有显著性（P〈0．05）。2～3岁组及4～18岁组鸡蛋不耐受阳性率分别为95．5％和89．5％，均明显高于≤1岁组（29．0％，P〈0．05）。1种食物不耐受发生率在≤1岁组（61．3％）明显高于2～3岁组（26．1％）和4～18岁组（31．5％），差异有显著性（P〈0．01）；2种及2种以上食物不耐受发生率在2～3岁组（73．9％）最高，明显高于≤1岁组（38．7％，P〈0．01），与4～18岁组（68．5％），差异无显著性（P〉O．05）。结论：儿童食物不耐受可引起多系统疾病，鸡蛋和牛奶是主要的不耐受食物，对疑似患儿进行食物特异性IgG抗体检测有助于疾病的治疗和预防。
Objective： To analyze the clinical manifestations of food intolerance in children, thus provide clinical evidence for the diagnosis and treatment of food intolerance in children. Methods： The serum allergen specific IgG antibodies to 14 kinds of food （including beef, chicken, cod, corn, crab, egg, mushroom, milk, pork, rice, shrimp, soybean, tomato, wheat） were detected with ELISA in 333 children who were highly suspected for food intolerance and underwent inefficient drug therapy, the results were analyzed in children according to their different ages. Results： Of 333 children suspected for food intolerance, 312 showed positive allergen specific IgG. The cases with different clinical symptoms： respiratory system symptoms in 105 cases, digestive system symptoms in 53 cases, skin symptoms in 42 cases, nervous system symptoms in 29 cases, malnutrition in 26 cases, precordial discomfort in 22 cases, urinary system symptoms in 11 cases, and other symptoms in 24 cases. The top four positive foods were egg, milk, soybean and tomato. The positive rate of milk intolerance was highest （79.0%） in the group of less than 1 year old, and lowest （63.0%） in the group of 4-18 years old, showing significant difference （P〈0.05）. Egg intolerance rate in the groups of 2-3 years old and 4-18 years old were 95.5% and 89.5%, respectively, they were both higher than that in the group of less than 1 year （29.0%, P〈0.05）. The incidence of intolerance to a single food was obviously higher in group of less than 1 year （61.3%） than in groups of 2-3 （26.1%） and 4-18 years old （31.5%）, showing significant differences （P〈0.01）. The incidence of intolerance to 2 or more than 2 kinds of food was highest in group of 2-3 years old （73.9%）, which was significantly higher than that in the group of less than 1 year （38.7%, P〈0.01）, but had no significant difference with that in group of 4-18 years old （68.5%, P〉0.05）. Conclusions： Multisystem diseases in children can be induced by foo
出处
《感染．炎症．修复》
2016年第3期157-160,共4页
Infection Inflammation Repair
关键词
儿童
食物不耐受
食物特异性IgG抗体
Children
Food intolerance
Food allergen specific IgG antibody
