摘要
目的通过对头颈部炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor,IMT)和炎性假瘤(inflammatory pseudotumor,IPT)的临床特点、组织学形态、免疫表型及随访进行综合分析,探讨IMT与IPT是否为同一肿瘤实体。方法回顾性分析108例IMT/IPT的临床病理学特征、免疫表型、治疗及随访,并复习相关文献。结果根据组织学分组标准筛选出36例IMT,72例IPT。IMT组织病理学特点:梭形细胞肿瘤性增生,炎细胞以浆细胞浸润为主,SMA大部分染色阳性,可见双轨征;IPT组织病理学特点:纤维结缔组织增生,炎细胞以淋巴细胞浸润为主,SMA染色阴性或小灶阳性。36例IMT中男性13例(36.1%),女性23例(63.4%),平均年龄39.4岁,好发于鼻腔鼻窦,20例复发(55.6%),1例颈部淋巴结转移,6例死亡。72例IPT中男性42例(58.3%),女性30例(41.7%),平均年龄50.1岁。IPT好发于眼眶,12例复发(16.7%),2例死亡。统计结果显示两组间患者的性别、年龄、原发部位、复发率、病死率、总生存率、无病生存率差异均有显著性(P均<0.05)。结论头颈部IMT是不同于IPT的肿瘤实体。
Purpose To analyze the clinical features of inflammatory myofibroblastic tumor（ IMT） and inflammatory pseudotumor（ IPT）,histopathologial and immunohistochemical staining characteristics and follow-up results,in order to study whether the IMT and IPT is a same tumor entity. Methods 108 cases of IMT / IPT in head and neck were obtained and the clinical characteristics,correlation treatment and follow-up results were reviewed. Results According to the histological criteria,36 cases of IMT and 72 cases of IPT were selected. The histopathologic features of IMT included that spindle cells were hyperplasia,admixed with a prominent infiltrate of plasma cells. The SMA expression presented as a peripheral rim（ a linear staining pattern）. IPT was composed of proliferation of fibrous connective tissue. The major inflammatory cells were lymphocytes. The staining of SMA was negative or focally positive. In the36 IMTs,13 cases（ 36. 1%） were male,23 cases（ 63. 4%） were female,with average age of 39. 4 years. The tumors were more likely to occur in sinonasal cavity. 20 cases（ 55. 6%） had recurrence. One case had cervical lymph metastasis and 6（ 20%） patients died of the disease. In 72 IPT patients,42（ 58. 3%） cases were male,30（ 41. 7%） cases were female,with an average age of 50. 1years. The lesions were more likely to occur in the orbit,12（ 16. 7%） cases had recurrence and 2 case were died of the disease.There were significant differences between IMT and IPT groups in gender,age,primary site,recurrence rate,mortality,overall survival and event-free survival（ both P 〈 0. 05）. Conclusion IMT in head and neck is a different tumor entity from IPT.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2015年第12期1356-1360,共5页
Chinese Journal of Clinical and Experimental Pathology
基金
鼻病研究北京市重点实验室资助(2014BBYJ02)
关键词
头颈部肿瘤
炎性肌纤维母细胞瘤
炎性假瘤
组织病理学
鉴别诊断
head and neck neoplasms
inflammatory myofibroblastic tumor
inflammatory pseudotumor
histopathology
differential diagnosis
