摘要
目的:总结国内外肿瘤疫苗的临床研究现状。方法:以"肿瘤细胞疫苗、肽疫苗和树突状细胞疫苗"等为关键词,计算机检索CNKI及PubMed数据库,检索年限为2002-2013。纳入标准:1)肿瘤疫苗处于临床试验阶段;2)肿瘤疫苗用于治疗黑色素瘤、肺癌和卵巢癌等实体瘤;3)肿瘤疫苗的靶点是新发现的或者正处于研究的热点。剔除标准:肿瘤疫苗仍处于动物实验阶段。最终纳入46篇文献。结果:大量的肿瘤疫苗已经投入到临床试验,用于实体瘤的治疗并显示出各自的特点。肿瘤细胞疫苗免疫原性较低,常需与佐剂联用才能有效诱导免疫应答;肽疫苗易于合成,靶向性强,但具有MHC限制性,能诱导特异性T细胞免疫应答;DC疫苗作为一种融合疫苗,显示出强烈的免疫原性及抗瘤活性;核酸疫苗的可修改性强,能激活特异性的体液免疫反应;抗ID-抗体疫苗制备繁琐而产量高,免疫反应强,安全性好。结论:目前取得突破性进展的肿瘤疫苗很少,但其作为肿瘤免疫治疗的方案具有极大的研究价值。特别是采用融合疫苗能更有效地激发患者的抗瘤免疫反应,改善临床效应。
OBJECTIVE： To review the recent clinical studies of cancer vaccines. METHODS： By cancer cell vaccine, peptide vaccine,dendritic cell vaccine etc as keywords, the papers of literature were collected by electronically searching CNKI and Pubmed （2002--2013）. Retrieval criteria： 1） The cancer vaccines were in clinical trials;2） The cancer vaccines were used for the treatment of melanoma,lung cancer,ovarian cancer or other solid tumors; 3） The targets of cancer vac- cines were newly discovered or in hot researches. Exclusion criteria：The cancer vaccines were still in animal studies. Forty- six articles were selected for inclusion of the review. RESULTS： Large numbers of cancer vaccines have been put into clini- cal trials for the treatment of solid tumors,showing their own advantages and disadvantages. Due to lower immunogenici- ty, tumor cell vaccines are often used in combination with adjuvants to induce immune response effectively. Peptide vac- cines are synthesized easily with strong targeting property and MHC restriction. They are able to induce specific T cell im- mune response. As a kind of fusion vaccines,dendritic cell vaccines show strong immunogenicity and anti-tumor activity. DNA vaccines can be modified to meet the needs of researchers and activate specific humoral immune response. Anti-idio- type-antibody vaccines are produced complicatedly with high yield, showing strong immune response and good security. CONCLUSIONS：Until now,the cancer vaccines which have got a breakthrough are rare. However,they are valuable in re- searches as the way of cancer immunotherapy. Especially using fused vaccines can stimulate anti-tumor immune response and improve the clinical effect more effectively.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2014年第5期395-400,共6页
Chinese Journal of Cancer Prevention and Treatment
关键词
肿瘤疫苗
肿瘤免疫治疗
临床试验
抗瘤免疫反应
cancer vaccine
tumor immunotherapy
clinical trial
anti-tumor immune response ..
