摘要
目的:探讨肠道病毒71型(enterovirs 71,EV71)和柯萨奇病毒A组16型(Coxsachie virus,CoxA16)所致的手足口病患儿的临床表现、生命体征及实验室检查的差异性,并指导临床治疗.方法:回顾性分析我院2011-08/2013-02收治的手足口病患儿的临床资料及预后.结果:EV71患儿中男童占68.9%,男童比例低于CoxA16组(2=5.6,P<0.05).CoxA16患儿的平均年龄为2.2岁±0.6岁,住院时间为4.6 d±0.8 d,均低于EV71患儿组(平均年龄为3.4岁±1.0岁,住院时间为6.1 d±1.6 d),P<0.01,差异具有统计学意义.CoxA16患儿的流涎和口腔溃疡的发生率较高,而呕吐、嗜睡及抽搐的发生率较低.并且其最高体温(38.2℃±0.9℃)、心率(122次/min±21次/min)、呼吸频率(26次/min±6次/min)、最高收缩压(98 mmHg±7 mmHg)及舒张压(64 mmHg±9 mmHg)方面的水平也均低于EV71患儿组,P<0.01,差异具有统计学意义.EV71患儿的乳酸脱氢酶(lactic acid dehydrogenase,LDH)256.1 U/L±25.7 U/L,肌酸激酶(creatine kinase,CK)91.8 U/L±30.2 U/L,肌酸激酶同工酶(creatine kinase-MB,CK-MB)26.6 U/L±10.5 U/L以及C反应蛋白(C reactive protein,CRP)8.6 mg/L±3.2 mg/L均较高.结论:对于手足口病患儿,需要根据所感染病原体不同,加强临床观察,早期识别危重病例,及时进行有效的治疗.
AIM： To explore the differences in the clinical features, vital signs and laboratory findings for hand, foot and mouth disease （HFMD） caused by enterovirus 71 （EV71） and Coxsackie virus （CoxA16）.
METHODS： Clinical data for 116 children diagnosed with HFMD from August 2011 to February 2013 were retrospectively analyzed.
RESULTS： Boys accounted for 57.5% in the EV71 group, which was lower than that in the CoxA16 group （χ2 = 5.6, P 〈 0.05）. The average age was younger and hospital stays was shorter in the CoxA16 group than in the EV71 group （2.2 ± 0.6 years vs 3.4 ± 1.0 years; 6.1 ± 1.6 d vs 4.6 ± 0.8 d）. The incidence of salivation and dental ulcer was higher in the CoxA16 group, but the performance of vomiting, drowsiness, hyperspasmia, highest body temperature （38.2？℃ ± 0.9？℃）, heart rate （122/min ± 21/min）, respiratory rate （26/min ± 6/min）, highest systolic blood pressure （98 mmHg ± 7 mmHg）, highest diastolic blood pressure （64 mmHg ± 9 mmHg） in the CoxA16 group were all lower than those in the EV71 group. In addition, serum levels of lactic acid dehydrogenase （LDH） （256.1 U/L ± 25.7 U/L）, creatine kinase （91.8 U/L ± 30.2 U/L）, creatine kinase-MB （26.6 U/L ± 10.5 U/L） and C reactive protein （8.6 mg/L ± 3.2 mg/L） in the EV71 group were higher.
CONCLUSION： Children with HFMD should be differentially treated depending on distinct pathogens. Clinical observations should be strengthened to help identify critical cases early and offer them effective treatment.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第30期3301-3305,共5页
World Chinese Journal of Digestology
关键词
手足口病
肠道病毒
临床比较
Hand, foot and mouth disease
Enterovirus
Comparative analysis
