摘要
目的探讨中西医结合治疗胃肠道恶性肿瘤的临床疗效。方法选取2010年1月—2012年1月本院收治的胃肠道恶性肿瘤患者146例,随机分为对照组和治疗组,每组73例。对照组给予单纯5-氟尿嘧啶+奥沙利铂治疗,治疗组在对照组基础上加用中药汤剂联合治疗。观察并比较2组近期临床疗效、不良反应、生活质量及生存期等指标。结果治疗组总有效率为43.84%,对照组为41.10%,2组无显著差异(P>0.05);治疗组胃肠道反应发生率、白细胞减少率及贫血发生率依次为49.32%、38.36%、31.51%,均明显低于对照组的63.01%、53.42%、43.84%(P<0.05);治疗组行为状态改善率及体质量变化率分别为52.05%和27.40%,均明显高于对照组的39.73%和12.33%,差异均有统计学意义(P<0.05)。结论中西医结合治疗胃肠道恶性肿瘤疗效确切,不良反应少,能显著改善患者的生活质量,值得临床推广。
Objective To explore clinical efficacy of integrative treatment for malignant gas- trointestinal cancer. Methods One hundred and forty- six patients with gastrointestinal cancer from our hospital between January 2010 to January 2012 were selected and were randomly divided into control group ( n = 73) and treatment group ( n = 73). The control group was administered 5 - fluorouracil + oxaliplatin regime, while the control group received additional integrative decoction on the regime of the control group. Recent clinical efficacy, adverse reactions, quality of life, sur- vival and other indicators in both groups were observed and compared. Results The efficacy rates in the treatment group and the control group were 43.84 % and 41.10 %, respectively. The differ- ence was not statistically significant (P 〉0.05). Gastrointestinal reactions, leukopenia rate and in- cidence of anemia in the treatment group were 49.32%, 38.36%, and 31.51%, respectively, which were significantly lower than the 63.01%, 53.42% and 43.84% in the control group (P〈 0.05). Improvement rate in performance status and rate of weight changes in the treatment group were 5 2.0 5 % and 2 7.4 0 % , respectively, which were markedly higher than the 3 9.7 3 % and 12.33 % in the control group. The differences were statistically significant (P 〈 0.05). Conclusion Integrative medicine is effective in treating malignant gastrointestinal with less adverse reactions and it can notably improve the quality of life of patients. Thus it is worthy of clinical promotion.
出处
《实用临床医药杂志》
CAS
2013年第17期132-133,136,共3页
Journal of Clinical Medicine in Practice
关键词
中西医结合
胃肠道
恶性肿瘤
integrative medicine
gastrointestinal tract
malignant