摘要
目的探讨肺结核病人合并肺部感染病原菌分布和耐药情况,为肺结核病人合并肺部感染治疗提供参考。方法分析近4年来本院结核病房住院病人182份痰液的病原菌分布和耐药情况。结果 182例痰标本检出124株病原菌,检出率为68.1%;病原菌以革兰阴性菌为主(95株,76.6%),革兰阳性菌11株(8.9%),真菌18株(14.5%);肺炎克雷伯菌和大肠埃希菌产超广谱β-内酰胺酶(ESBLs)的检出率分别为41.7%(15/36)和42.9%(6/14);对革兰阴性菌敏感性较高的主要包括亚胺培南、头孢吡肟、头孢他啶、哌拉西林、环丙沙星和妥布霉素。结论肺结核病人合并肺部感染病原菌主要为条件致病菌,耐药广泛,需加强病原菌分离和耐药性监测。
In order to explore the pathogenic distribution and antimicrobial-resistance of tuberculosis patients suffered from lung infection,and to help providing the reference data for the treatment,we analyzed the bacterial distribution and antimicrobial-resistance of 182 sputum samples from hospitalized patients of tuberculosis for nearly four years.The results showed that 124 pathogen were isolated in 182 sputum samples（68.1%）;Gram-negative bacteria were the major pathogens（95,76.6%）,the next were gram-positive bacteria（11,8.9%）and fungi（18,14.5%）;Extended-spectrumβ-lactamases（ESBLs）-producting of Escherichia coli and Klebsiella pneumoniae is 41.7%（15/36） and 42.9%（6/14）,respectively.Highly sensitive to Gram-negative bacteria included Imipenem,Cefepime,Ceftazidime,Piperacillin,Ciprofloxacin and Tobramycin.The main pathogen of tuberculosis patients suffered from lung infection is opportunistic bacteria and extensively drug-resistant tuberculosis.Therefore,we should strengthen the work of pathogen isolation and drug-resistance surveillance.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2011年第5期464-464,F0003,共2页
Chinese Journal of Zoonoses
基金
全球结核病控制医防合作项目基金资助
关键词
肺结核
肺部感染
病原菌
Tuberculosis
lung infection
pathogen
