摘要
目的研究生长激素缺乏(GHD)矮小儿童临床表现与垂体MRI之间的关系。方法回顾性分析因矮小住院38例(男23例、女15例;年龄5～14岁。其中10例处于青春发育期,TannerⅡ～Ⅲ期)临床确诊为GHD矮小患儿的垂体MRI检查结果,观察其垂体形态、大小、信号及垂体柄形态和位置。应用SPSS12.0软件进行统计学分析。结果GHD患儿中20例垂体形态为中间平坦形(53%),17例为中间凹陷形(45%),1例隆凸形。完全GHD的22例患儿中,18例有不同程度腺垂体发育不良,垂体柄异常和(或)垂体信号的改变,其中5例神经垂体高信号消失,4例表现为垂体柄阻断综合征;另4例垂体完全正常。16例部分GHD的患儿中,7例有不同程度垂体大小和(或)垂体柄异常,8例垂体完全正常,1例为垂体腺瘤。结论垂体MRI检查可协助GHD患儿的诊断及垂体病变程度的评价。
Objective To study the relationship between the clinical manifestations and changes of pituitary magnetic resonance imaging （MRI） in short stature children with growth hormone deficiency（GHD）. Methods The pituitary MRI finding in 38 cases of short stature children diagnosed as GHD（ males 23 ,females 15 ;5 - 14 years old, 10 children were in pubertas and Tanner Ⅱ - Ⅲ ） were analyzed, and the pituitary morphology, size, signal and pituitary stalk＇s shape and location were observed. SPSS 12.0 software was used to analyze the data. Resuits The forms of pituitery were plaque in 20 children（53% ） ,cupped in 17 children（45% ） ,and carinate in 1 children. In the 22 cases of completely GHD, 18 cases had different levels of anterior pituitary dysplasia, abnormal pituitary stalk and/or pituitary signal changes,5 cases without posterior lobe disappeared high signal and 4 cases with pituitary stalk interruption syndrome ; the other 4 cases had completely normal pituitary. In the 16 cases of partially GHD ,7 cases had varying degrees of pituitary size and/or abnormal pituitary stalk ,8 cases had completely normal pituitary, and 1 case had pituitary adenoma. Conclusion Pituitary MRI could assist diagnosis and evaluate pituitary function in short stature children.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2009年第20期1569-1570,共2页
Journal of Applied Clinical Pediatrics
关键词
生长激素缺乏
矮小
垂体
磁共振
儿童
growth hormone deficiency
short stature
pituitary
magnetic resonance imaging
child
