摘要
乙型脑炎(乙脑)的流行是世界性的公共卫生问题之一,其流行范围正逐步扩大。目前对于乙脑尚无特效治疗手段,因此预防乙脑的发生尤为重要。随着对日本脑炎病毒研究的深入,利用基因工程技术研制新型候选疫苗已成为预防乙脑新的发展方向。我们简要综述了乙型脑炎病毒的基因组结构及其蛋白功能,以及国内外乙型脑炎疫苗研发的新进展。
Japanese encephalitis virus（JEV） is one of globally important human pathogens.Despite an emergence and resurgence of JEV-mediated disease,specific therapies are not yet available.Thus,it is important to prevent and take precautions against the flavivirus infections.Sevaral new promising Japanese encephalitis vaccine candidates have been developed.In this article we reviewed on JEV genomic structure and their function,recent advances in the area of Japanese encephalitis vaccine development.
出处
《生物技术通讯》
CAS
2009年第5期706-709,共4页
Letters in Biotechnology
关键词
日本脑炎病毒
乙型脑炎
疫苗
Japanese encephalitis virus
Japanese encephalitis
vaccine
