摘要
The renin angiotensin system (RAS) is emerging as a prominent factor in the development of experimental atherosclerosis. We have previously demonstrated that the RAS is profoundly activated in hypercholesterolemia. This was demonstrated in LDLR-/-mice fed a saturated fat enriched diet and manifested as increased plasma concentrations of angiotensinogen and angiotensin peptides; especially angiotensin Ⅱ (AngⅡ).
The renin angiotensin system （RAS） is emerging as a prominent factor in the development of experimental atherosclerosis. We have previously demonstrated that the RAS is profoundly activated in hypereholesterolemia. This was demonstrated in LDLR-/-mice fed a saturated fat enriched diet and manifested as increased plasma concentrations of angiotensinogen and angiotensin peptides ; espe- cially angiotensin Ⅱ（ Ang Ⅱ ）. Many of the functions of AngⅡ are via activation of AT1 a receptors.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2009年第7期573-573,共1页
Chinese Journal of Arteriosclerosis
关键词
肾素
动脉粥样硬化
临床分析
血管
Renin Angiotensin System
Atherosclerosis
LDLR-/-
