摘要
目的了解综合性医院病原菌分布及耐药情况,以便合理地为临床提供抗菌药物应用策略。方法对近4年各临床科室送检标本检出的病原菌进行菌株鉴定,用K-B法做体外药敏试验。结果在1643例分离到的细菌中,以革兰阴性菌铜绿假单胞菌、大肠埃希菌及革兰阳性菌表皮葡萄球菌、金黄色葡萄球菌为主;且铜绿假单胞菌对广谱青霉素、第三代头孢、氨基糖苷类和喹诺酮类抗菌药物均显示高耐药率,但亚胺培南对所有革兰阴性杆菌有较强抗菌活性,耐药率均<6.52%。结论加强对综合性医院病原菌分布,耐药性连续监测,对临床合理用药,减少耐药菌产生具有重大意义。
OBJECTIVE To investigate the distribution and resistance of commonly encountered pathogens in a General Hospital, and provide reference for antimicrobial agents usage. METHODS All pathogenic bacteria were isolated from the clinical specimens during the last four years and samples were identified. K-B method was performed to test the antibiotic resistance. RESULTS Among 1643 isolates, The Gram-negative bacteria Pseudomonas aeruginosaand Escherichia coli, and the Gram-positive bacteria Staphyococcus epidermidisand S. aureus were the main pathogens. The P. aeruginosa was highly resistant to broad-spectrum penicillins, third-generation cephalosprins, aminoglycosides and quinolones. But impenem showed activity against Gram-negative bacilli, with resistant rates less than 〈6.52%. CONCLUSIONS Strengthening continuous surveillance of drug resistance of pathogens in a general hospital can be useful for antibiotic usage reasonably.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第3期335-337,共3页
Chinese Journal of Nosocomiology
关键词
病原菌
分布
耐药率
抗菌药物
Pathogen
Distribution
Drug resistance rate
Antibiotics
