摘要
2例患者在手术中使用琥珀酰明胶注射液发生过敏性休克。第1例为16岁女性患者,在行恶性神经鞘瘤切除术过程中静脉滴注琥珀酰明胶,输入20～30ml后,患者血压突然下降至26/20mmHg,HR150次/min,全身皮肤呈橘皮样改变。立即停止手术,给予抗过敏、抗休克治疗后好转。3d后再行手术,麻醉方法同前,无不良反应发生。第2例为46岁女性患者,因卵巢癌术后复发,再次开腹探查,术中应用琥珀酰明胶静脉滴注。输入约100ml时,患者血压突然下降至40/20mmHg,球结膜水肿。立即停药,给予抗过敏、抗休克治疗后好转,继续手术。
Two patients receiving succinylated gelatin injection during surgery developed anaphylactic shock. Patient 1, a 16-year-old woman received an IV infusion of succinylated gelatin during undergoing malignant schwannoma resection. After infusion of 20-30 ml, her BP suddenly fell to 26/20 mmHg with a HR of 150 beats/min, and her generalized skin had an ‘orange peel＇ appearance. The surgery was stopped immediately. Her condition improved after antianaphylactic and anti-shock treatment. Three days later, she underwent surgery again. The anesthesia remained the same and no adverse reactions occurred. Patient 2, a 46-year-old woman underwent an exploratory laparotomy for recurrence of postoperative ovarian cancer. She received an IV infusion of succinylated gelatin during surgery. After infusion of about 100 ml, her BP abruptly fell to 40/20 mmHg, and her chemosis occurred. The medication was withdrawn at once and her condition improved after antianaphylactic and anti-shock treatment. Her surgery was continued.
出处
《药物不良反应杂志》
2008年第6期448-448,450,共2页
Adverse Drug Reactions Journal
关键词
琥珀酰明胶注射液
过敏性休克
不良反应
succinylated gelatin injection
anaphylactic shock
adverse reaction
