摘要
目的观察不同时间胃管给予清胰汤及生大黄灌肠对SAP的治疗效果，探讨其早期应用的重要性。方法将符合诊断标准的SAP患者按随机分组法分成12h治疗组（n=34）和72h治疗组（n=27），两组分别于发病后12h和72h后给予生大黄灌肠和清胰汤胃管注入。比较两组血清TNF-α、CRP水平及APACHEⅡ评分、腹痛缓解所需天数、住院天数与住院费用。结果12h治疗组发病72h后血清TNF-α、CRP水平分别为（265±66）U／ml、（32．1±7．1）mg／L，APACHEⅡ评分为6．3±2．0，腹痛缓解需（4±2）d，平均住院（18±5）d，费用（4．2±1．8）万元；而72h治疗组分别为（491±81）U／ml、（43．5±11．0）mg／L、9．1±1．8、（8±3）d、（34±8）d、（7．1±2．6）万元，两组差异均有统计学意义（P〈0．05）。结论早期应用清胰汤胃管注入及生大黄灌肠治疗SAP效果更好。
Objective To investigate the optimal initial timing of Qingyi Decoction and clyster with rhubarb in patients with severe acute pancreatitis （SAP）. Methods Patients with SAP were randomly divided into 2 groups. The group A （ n = 34） received clyster with rhubarb and Qingyi Decoction after 12 h of SAP onset and the group B （ n = 27 ） received sameltherapy after 72 h of onset of SAP. The serum levels of TNF-α, CRP and APACHE Ⅱ scores, time to abdominal pain cessation, length of hospital stay and medical costs were compared. Results The serum levels of TNF-α and CRP of patients in group A were （265 ± 66） U/ml, （32.1 ± 7.1 ）mg/L, and the score of APACHEⅡ were 6.3 ± 2.0, time to abdominal pain cessation was （4 ± 2）d, length of hospital stay was （ 18 ± 5 ） d, medical costs was （42 000 ± 18 000） yuan; while the corresponding values in the group Bwere （491 ±81）U/ml, （43.5±11.0） mg/L, 9. 1 ±1.8, （8 ±3）d, （34±8）d, （71 000 ±26 000） yuan, and the difference was statistically significantly （ P 〈 0.05 ）. Conclusions Qingyi Decoction and clyster with rhubarb should be given in the early phase of SAP in order to achieve better outcomes.
出处
《中华胰腺病杂志》
CAS
2008年第5期324-325,共2页
Chinese Journal of Pancreatology
关键词
胰腺炎
急性坏死性
大黄
灌肠
清胰汤
Pancreatitis, acute necrotizing
Rhubarb
Enema
Qingyi decoction
