摘要
目的:研究脑出血微创血肿清除术对血清超氧化物歧化酶(SOD)和丙二醛(MDA)的影响,探讨微创血肿清除术的脑保护作用。方法:80例急性脑出血患者分为动脉粥样硬化对照组、微创术组和内科治疗组,生物化学法测定入院时及治疗后2、3、5、7、10d血清SOD和MDA水平,评估神经功能缺损程度评分(neurological deficiency score,NDS)和日常生活能力评分(activity daily living,ADL)。结果:微创术组SOD浓度较内科组明显增高(P<0.05),MDA浓度显著降低(P<0.05),NDS有不同程度降低(P<0.05),ADL有不同程度增高(P<0.05)。结论:微创血肿清除术能使急性脑出血患者血清SOD浓度增高、MDA浓度降低,可以通过增强自由基清除发挥脑保护作用。
Objective To observe the effects of mini-invasive hematoma aspiration on serum superoxide dismutase （SOD） and malondialdehyde （MDA） in patients with cerebral hemorrhage. Methods Eighty patients with intracerebral hemorrhage were divided into three groups, including control group with arteriosclerosis, aspiration treatment group and conservative treatment group. SOD and MDA were measured by biochemistry. Neurological deficiency score （NDS） and activity daily living（ADL） were examined. Results The serum SOD activity was significantly higher in aspiration group than that in conservative group （P 〈 0.05）. The serum MDA level was significantly lower in aspiration group than that in conservative group （P 〈 0.05）. The NDS was significantly lower in aspiration group than that in conservative group（P 〈 0.05）. The ADL was significantly higher in aspiration group than that in conservative group（P 〈 0.05）, Conclusion Mini-invasive hematoma aspiration for cerebral hemorrhage can increase the serum SOD activity and decrease the MDA level; it may be beneficial for protecting neural function by enhancing clearance of free radical.
出处
《实用医学杂志》
CAS
2008年第10期1735-1737,共3页
The Journal of Practical Medicine
关键词
颅内出血
超氧化物歧化酶
丙二醛
微创血肿清除术
Intracranial hemorrhages Superoxide dismutase Malondialdehyde Mini-invasive aspiration
