摘要
目的评价胃镜下激光光动力（Laser photodynamic，LPD）治疗晚期胃癌的临床疗效，以及临床疗效与胃癌组织病理分型和分级之间的关系。方法在胃镜下采用LPD治疗晚期胃癌129例，HE染色对癌组织进行病理分型与分级，治疗后利用胃镜、病理活检及其他化验检查对患者的生存状况进行随访。结果经LPD治疗2～3个疗程，有效率为96．1％，6，12，18，24和30个月的累积生存率分别为93．8％、84．3％、72．5％、61．3％和48．5％，无严重并发症，临床疗效与组织病理分型和分级之间差异均无显著性（P〉0．05）。结论LPD是治疗晚期胃癌理想的姑息性方法之一，能最大程度缩小瘤体，提高了患者的生活质量，延长了患者的生存时间，临床疗效与组织病理分型和分级无相关性。
Objective To evaluate the clinical efficacy of laser photodynamic （LPD） in treat ment of the patients with advanced gastric cancer（GC） ,and the correlation between the clinical efficacy and the histopathologic type and grade. Methods LPD was used to treat 129 patients with advanced GC. Hematoxylin and eosin staining was used for histopathologic typing and grading of GC. Survival condition of patients was followed up using gastroscopy, pathological biopsy and relative examinations. Results Effective rate was 96. 1% after two to three courses of therapy with LPD. Cumulative survival rates of six months, twelve months ,eighteen months ,twenty-four months and thirty months of the treatment group were 93. 8% ,84. 3%, 72. 5% ,61.3% and 48.5%, respectively. There was no severe complication. There was correlation between the clinical efficacy and pathologic type and pathologic grade（ P 〉 0. 05 ）. Conclusions LPD is one of conservative treatment methods for advanced GC. LPD can minimize tumor volume, improve quality of life and prolong survival time of patients. There is no correlation between the clinical efficacy and pathologic type and pathologic grade.
出处
《中国肿瘤临床与康复》
2008年第3期201-203,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
激光光动力
胃肿瘤
组织病理分型
分级
Laser Photodynamic
Advanced gastric cancer
Histopathologic typing and grading
