摘要
【目的】探讨苦参素注射液治疗慢性丙型肝炎肝硬化合并糖尿病的效果。【方法】将86例慢性丙型肝炎肝硬化合并糖尿病患者随机分为静滴苦参素治疗组(A组)和基础保肝治疗对照组(B组),疗程均为3个月。【结果】治疗前后肝功能复常率、血糖好转率、HCV-RNA转阴率有明显差别(P<0.05)。肝纤维化指标透明质酸酶(HA)、Ⅲ型前胶原(PCⅢ)治疗后有明显下降(P<0.01),且苦参素治疗组未见明显不良反应。【结论】苦参素注射液对促进肝功能恢复、血糖好转和抑制丙肝病毒复制有一定效果,具有明显的抗纤维化的作用。
[Objective] To discuss the results of treating chronic hepatic China and cirvrhosis of liver complicated with diabetus mellitus with marine and diabetes injection. [Methods] 86 patients with chronic hepatitis C or hepatitis cirrhosis were randomly divided into two groups： marine and glucose injection group （group A） and control group （group B）. The time of treatment length were three months. [Results] There was obvious difference in the recovery rates of liver function and growing negative rates of HCV-RNA before and after treatment. （P 〈 0.05）. There was tremendous decrease in HA, PcⅢ after treatment and there was no side-effect in group A. [Conclusions] It is found that better therapeutic effect in promoting liver function, restarting hepatic viruses from replication and controlling hepatic fibrosis.
出处
《武警医学院学报》
CAS
2008年第5期426-427,430,共3页
Acta Academiae Medicinae CPAPF
关键词
苦参素注射液
慢性丙型肝炎
肝硬化
糖尿病
Matrine and glucose injection
Chronic hepatitis C
Cirrhosis
Diabetes
