摘要
目的:观察凉血生肌中药防治冠状动脉介入术后再狭窄的临床疗效。方法:冠状动脉介入术成功的冠心病患者,按随机方案分为两组,对照组给予常规西药治疗,治疗组加用凉血生肌中药(生黄芪、丹参、丹皮、金银花)2个月。随访6个月,进行冠状动脉造影复查,同时观察心源性死亡、急性心肌梗死、心绞痛、严重心衰、再介入和冠脉搭桥的情况;随访截至2007年4月。结果:①共纳入患者100例,治疗组52例,对照组48例,两组基线情况比较差异无统计学意义,具有可比性。②完成随访97例,依据造影结果和复发心绞痛情况估计再狭窄率,治疗组有减少再狭窄发生的趋势(7/51,13/46),但两组比较未达到统计学意义(P>0.05)。③治疗组联合心血管事件的发生率明显降低(9/51,17/46),(P<0.05);生存分析表明中药治疗可以减少发生联合心血管事件的风险,益处在干预后6个月明显显现(P<0.05)。④未见明显的不良反应。结论:冠心病介入术后服用凉血生肌中药有减少造影再狭窄和复发心绞痛发生的趋势,能明显降低联合心血管事件的风险。
Objective： To observe the clinical effects of blood-cooling and muscle-growing herbs on restenosis after percutaneous coronary intervention （PCI）. Methods： Coronary heart disease patients undergoing successful PCI were randomly divided into two groups. The control group was treated with conventional western medicine, the treatment group was given blood-cooling and muscle-growing herbs in addition for 2 months. The patients were followed up for 6 months, coronary angiography was performed and cardiovascular events such as sudden death, acute myocardial infarction, angina, severe heart failure, revascularization, were observed. Results： ①100 cases were involved in this trial, 52 cases in the treatment group and 48 cases in the control group. No significant difference was found between two groups in clinical characteristics. （2）97 cases finished the follow-up survey. The angiographic resuhs and angina after PCI showed that restenosis ratio had a declining trend in the treatment group, 7/51 （treatment） vs 13/46 （control）, but there was no significant difference （P 〉 0.05）. ③The incidence of cardiovascular events of the treatment group was reduced as compared with that of the control group , 9/51 （control）vs17/4（treatment）, P 〈 0.05. Through a survival analysis, the benefit of Chinese medicine was showed 6 months after treatment. ④No severe adverse reaction was found in this trial. Conclusion： Patients treated with blood-cooling and muscle-growing herbs after PCI were found a tendency of reducing angiographic restenosis and angina after PCI. Chinese herbs can reduce lipid risk efficiently.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2008年第2期161-164,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家中医药管理局基金资助项目(No.国中医药科02-03LP09)
关键词
冠状动脉介入术
心血管事件
再狭窄
中药
凉血生肌
Percutaneous coronary intervention
Cardiovascnlar events
Restenosis
Chinese medicine
Blood-cooling and muscle-growing herbs
