摘要
目的探讨a-L-岩藻糖苷酶(a-L-fucosidase,AFU)与甲胎蛋白(alpha fetoprotein,AFP)联合检测在原发性肝癌诊断中的临床意义。方法对1992年￣2000年在普外科和消化内科门诊及住院的358例原发性肝癌,628例良性肝病,52例肝癌介入化疗术后患者,28例转移性肝癌,81例其他肿瘤,251例正常对照者,以AFU>600(nmol/ml.h)为阳性标准,用酶标法检测。以AFP>20(ng/ml)为阳性标准,用放免法检测。绘制受试者工作特性曲线(receiver operating characteristic curve,ROC)并计算曲线下面积评价诊断价值。结果原发性肝癌(primaryhepatic carcinom,PHC)组血清AFU水平显著高于其他各组(P<0.01),AFP水平与慢性肝病组、其他肿瘤组、正常对照组相比差异有统计学意义(P<0.05)。PHC组和转移性肝癌组中AFU的检出率与AFP的检出率相比差异有统计学意义(P<0.05)。结论AFU可作为诊断PHC的一种较好的血清肿瘤标志物。AFU与AFP联合检测,可提高诊断PHC的敏感性,并可作为对PHC的疗效观察的一项指标。
Objective To study the clinical significance of combined serum a-L-fucosidase （AFU） and alpha-fetoprotein （AFP） detection for the diagnosis of primary hepatic carcinoma. Methods In the department of general surgical and digestive internal medicine, 358 patients with primary hepatic carcinoma （PHC）, 628 patients with non- malignant liver disease, 52 patients with interventional therapy after chemotherapy and surgery, 28 patients with metastatic hepatic carcinoma, 81 patients with other tumor and 251 healthy persons were detected for AFU and AFP with methods of enzymology and radioimmunoassay. To evaluate the value of diagnosis, draw the receiver operating characteristic curve（ROC） and calculate the area under curve（AUC）. Results AFU activity in PHC team was distinctly higher than those in other teams （P〈0.01）. AFP activity in PHC team was distinctly higher than that in chronic liver disease team, other tumor team and healthy person team （P〈0.05）. The percentage of success on examing PHC team and metastatic hepatic carcinoma with AFU was distinctly higher than that with AFP（P〈0.05）. Conclusion AFU can be used as a good marker of detection of PHC. Combined AFU and AFP detection will enhance the sensitivity of the diagnosis of PHC,and can be used as a parameter to the PHC＇s curative effect.
出处
《肝胆胰外科杂志》
CAS
2007年第3期176-178,共3页
Journal of Hepatopancreatobiliary Surgery
