摘要
背景:质子泵抑制剂(PPI)埃索美拉唑和奥美拉唑广泛应用于消化性溃疡和反流性食管炎的治疗中,但目前内镜下治疗术后的应用研究较少。目的:比较埃索美拉唑与奥美拉唑对疣状胃炎氩离子凝固术(APC)后腹痛缓解和溃疡愈合的疗效。方法:86例疣状胃炎APC后随机分为两组:A组46例,治疗后次日起予埃索美拉唑20mg/d口服,疗程4周;B组40例,治疗后次日起予奥美拉唑20mg/d口服,疗程4周。观察治疗前后两组患者的腹痛缓解情况和溃疡愈合情况。溃疡愈合情况通过胃镜检查来评估。结果:A组患者服药后第1d腹痛缓解率为84.8%,高于B组的55.0%(P<0.001)。A组患者第7d腹痛缓解率为100.0%,高于B组的80.0%(P<0.01)。两组间疼痛消失平均天数比较,A组显著少于B组(P<0.001)。A组溃疡愈合率(95.7%)高于B组(92.5%),但差异无显著性(P>0.05)。结论:埃索美拉唑和奥美拉唑在疣状胃炎APC后溃疡的愈合方面具有相同疗效,但在腹痛缓解方面埃索美拉唑优于奥美拉唑。
Background： Esomeprazole and omeprazole are widely used in the treatment of peptic ulcer and reflux esophagitis, however, the use of these drugs following endoscopic treatment remains few. Aims： To compare the therapeutic efficacy of esomeprazole and omeprazole in treating postoperative abdominal pain and ulcer in patients with gastritis verrucosa following treatment by argon plasma coagulation （APC）. Methods： A total of consecutive 86 patients with gastritis verrucosa following treatment of APC was divided into group A and group B randomly. Group A （n=46） received esomeprazole 20 mg once a day and group B （n=40） omeprazole 20 mg per day for a course of four weeks. We observed and compared the abdominal pain relief and the ulcer healing through endoscopy between the two groups at the beginning and the end of study. Results： The remission rate of abdominal pain in group A was higher than that in group B on the first day of the treatment （84.8% vs. 55.0%, P〈0.001）, and on the seventh-day （100.0% vs. 80.0%, P〈0.01）. Comparing the average duration of abdominal pain relief, group A was significantly lower than group B （P〈0.001）. The rate of ulcer healing assessed by endoscopy in group A was higher than that in group B, but the difference was not significant （95.7% vs. 92.5%, P〉0.05）. Conclusions： Esomeprazole has the same effect as omeprazole for postoperative ulcer healing in patients with gastritis verrucosa followed by treatment of APC, but esomeprazole is more effective than omeprazole in abdominal pain relief.
出处
《胃肠病学》
2007年第4期224-227,共4页
Chinese Journal of Gastroenterology
关键词
埃索美拉唑
奥美拉唑
胃炎
氩离子凝固术
胃溃疡
Esomeprazole
Omeprazole
Gastritits
Argon Plasma Coagulation
Stomach Ulcer
