摘要
目的:不同剂量他汀类药对老年冠心病患者血脂及血清C-反应蛋白(CRP)浓度的影响。方法:将65例老年稳定性冠心病伴高脂血症患者随机分为低剂量治疗组(n=37)和高剂量治疗组(n=28),低剂量治疗组口服辛伐他汀20 mg/d,高剂量治疗组口服辛伐他汀40 mg/d;疗程均为6周。结果:疗程结束后两组血脂指标(TC、TGL、DL-C)及CRP均较治疗前降低(P<0.05),两组间结果差异无显著性意义(P>0.05)。两组均无不良反应发生。结论:他汀类药对老年冠心病患者也具有良好的降脂效应,且能有效降低患者的CRP,安全性亦好。
Objective：To study the influence of the different doses of simvastatin on blood lipid and C-reactive protein in elderly coronary heart disease. Methods： 65 elderly patients with stable cor onary heart disease accompanied with hyperlipidemia were divided into low dose group （oral 20mg/d simvastatin） and high dose group （oral 40mg/d simvastatin）. All patients were treated for 6 weeks and their blood lipid and blood CRP were measured and analyzed with statistics before and after treatment. Results： After 6 weeks treatment, the plasma levels of TC, TG, LDL-C and CRP were significantly decreased （P〈0.05） in both groups. HDL-C was significantly increased （P〈0.05） in the high dose group. Conclusion. The different doses of simvastatin can reduce the blood lipid and CRP safely in elderly patients with stable coronary heart disease with hyperlipidemia.
出处
《实用临床医学（江西）》
CAS
2006年第2期17-18,25,共3页
Practical Clinical Medicine
关键词
他汀类药
血脂
C-反应蛋白
老年冠心病
simvastatin
blood lipid
C-reactive protein
elderly coronary heart disease
