摘要
目的探讨并比较新疆雪莲培养物(TCSauI)乙醇提取物的抗辐射损伤作用。方法小鼠灌胃给予TCSauI乙醇提取物,剂量8.3、16.6、24.9 mg.kg-1,每天灌胃1次共30 d,于灌胃后第20天将对照组与试验组用60Coγ-ray照射,剂量1.0 Gy,每天1次共10次。观察小鼠体质量、外周白细胞数、SOD活性、骨髓嗜多染红细胞微核率和平均存活时间的变化。结果与空白给药组相比,TC-SauI醇提物能使受照射小鼠的外周白细胞数、SOD活性和平均存活时间显著增加(P<0.01),骨髓嗜多染红细胞微核率显著降低(P<0.01)。结论新疆雪莲培养物乙醇提取物具有抗辐射作用。
Objective To study the anti-radiation effect of the tissue culture of Saussurea involucrata Methods Anti-radiation effect was investigated in mice on body weight, white blood cell counts, serum superoxide dismutase （SOD） activity, survival rate, survival time and micronucleus rate. Results Compared with radiation group, the tissue culture of S. involucrata could obviously increase white blood cell counts and serum SOD activity（P 〈 0.01 ） and decrease micronucleus rate（P 〈 0.01）. The tissue culture of S. involucrata also showed a significant increase in the survival rate and the survival time （P 〈 0.01） of the animals subjected to radiation. Conclusions The tissue culture of S. involucrata has protective effect on irradiated mice.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2005年第6期444-448,462,共6页
Journal of Shenyang Pharmaceutical University
关键词
新疆雪莲
组织培养物
抗辐射作用
Saussureu involucrata
tissue culture
anti-radiation
