摘要
背景:胆石症是一种严重危害人类健康的常见病,流行病学研究表明近十年来胆石症发病率迅速上升。目的:综合分析我国胆石症发病的危险因素,为制定相关预防和控制策略提供参考依据。方法:对国内外1978年1月～2004年2月间公开发表的关于我国胆石症发病危险因素的独立病例对照研究进行Meta分析,计算每个因素的OR值以及95%CI。结果:共累积病例3145例,对照3812例。油腻饮食(2.49)、荤食习惯(2.19)、偏食动物油(2.19)、偏食动物内脏(2.20)、不吃早餐(2.03)、体重指数≥25(1.95)、高脂血症(1.67)、多孕次(1.47)、绝经(2.02)、胆道蛔虫病史(6.25)、胆囊炎病史(28.42)、胆石症家族史(3.36)、饮酒(1.54)、缺乏锻炼(2.39)、口服避孕药(2.50)为我国胆石症发病的主要危险因素;素食习惯(0.42)、饮牛奶(0.43)、农村饮深井水(0.51)、22时后就寝(0.55)为预防胆石症发生的保护因素。结论:改善膳食结构、吃早餐、饮牛奶、农村饮深井水、控制体重、女性减少孕次、少饮酒、加强锻炼、22时后就寝有助于预防胆石症的发生。
Background： Cholelithiasis is a common disease worldwide and many epidemiological studies have shown that the incidence of cholelithiasis is rapidly increasing in the last decade. Aims： To provide reference evidence for decisionmaking in cholelithiasis prevention through analyzing the risk factors related to the increasing incidence of cholelithiasis in China. Methods： The results of case-control studies on risk factors of cholelithiasis in China published domestically and abroad from January 1978 to February 2004 were analyzed bv recta-analysis method. The pooled odds ratio（OR）and 95% confidence interval（CI）of the risk factors were cah＇ulated. Results： The cumulative cases and controls were 3 145 and 3 812. respectively. Greasy food （2.49）, meat diet （2.19）, favoring of animal edible oil （2.19）, favoring of animal viscera （2.20）, having no breakfast （2.03）. body mass index≥25 （1.95）, hyperlipidemia （1.67）, multigravidity （1.47）, menopause （2.02）, history of bilialy ascariasis （6.25）. history of cholecvstitis （28.42）, family history, of eholelithiasis （3.36）, alcohol drinking （1.54）. lack of exercise （2.39）. taking contraceptive orally （2.50） were the main risk factors for cholelithiasis in China. Vegetable diet （0.42）, nfilk drinking （0.43）. deep-well water drinking （in the countryside） （0.51）, sleep after 22 p,m, （0.55） were the protective factors for prevention of cholelithiasis. Conclusions： Improving the dietary habit, breakfast eating, milk drinkiug, deep-well water drinking （in the countlyside）, body weight control, decreasing gravidity among women, decreasing of wine or liquor drinking, more exercises, and sleep after 22 p.m. are factors useful in prevention of cholelithiasis.
出处
《胃肠病学》
2005年第4期217-222,共6页
Chinese Journal of Gastroenterology
