摘要
根据硒与癌症的负相关关系和有机硒的生物活性可能更高，作者设计并合成了十一个取代苯亚硒酸化合物（Ⅳ＿（ａ～ｋ）。化合物经抑制乙酰胆碱脂酶，体外抗ＨＬ－６０和Ｋ５６２及抑制小鼠艾氏腹水癌实验，发现Ⅳ＿ａ和Ⅳ＿ｂ有较强的活性。Ⅳ＿ｂ抑制小鼠艾氏腹水癌的抑瘤率为２０．３０％（２０ｍｇ／ｋｇ），高于亚硒酸钠的１０．６５％（０．５ｍｇ／ｋｇ）。
In view of the negative
relationship be- tween selenium and cancer, we designed and synthe-sized eleven substituted
benzeneseleninic acids(Ⅳ_(a～k))The antienoplastic activity of the title compounds
wasevaluated via the tests of inhibition of acetyl-cholinestrase, HL-60 and K562 in Vitro,and
Ehrlichcarcinoma in mice.The result showed that the com-pounds Ⅳ,and Ⅳ_b and distinct
antieoplastic activity.The life span increase rate of Ⅳ_b on mice bearingEhrlich carcinoma was
20.30%(20mg/kg), which washigher than the increase rate of sodium selenite(10.
65%,0.5mg/kg)。
出处
《华西医科大学学报》
CSCD
1995年第4期371-374,共4页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
关键词
取代苯亚硒酸
合成
抗癌活性
Substituted benzeneseleninic acid Synthesis Antineoplastic activity
The project Supported by National Natural Science Foundation of China
