摘要
在２０％ＦｅＣｌ３致大鼠颈总动脉血栓模型上，血小板膜纤维蛋白原受体桔抗剂ＲＧＤｓ肽修饰的１４Ｃ－脂质体较单纯１４Ｃ－脂质体在血栓和血栓段血管组织的含量分别高出１６．５和１６．２倍（Ｐ＜０．０１）。用ＲＧＤＳ肽修饰的包裹尿激酶的脂质体溶栓，其疗效显著优于游离ＲＧＤＳ肽和尿激酶脂质体的混合液。结果提示用ＲＧＤＳ肽修饰脂质体能增强其靶向性溶栓效应。
n order to potentiate targeting of
liposomes carrying thrombolytic drugs liposomes were modifiedwith a
synthetic peptide Arg-Gly-Asp-Ser(RGDs),which is a specific
antagonist of fibrnogen receptor on platelet membrane.On the model of
20%-FeCla-induced thrombl of carotid arteries in rats,it was found
that the contenr of RGDS- modified14 C- liposomes in thrombi and
vascular tissues with throm bi were increasecd 17.5 and 17.2 times
respectively,compared with nonmodified
14C-liposomes.Futher-more,RGDS-mpdified liposmes encapsulated with
urokinase( UK)were used to thrombolyzc,we found that RGDS modified
liposomes encapsulated with UK had thrombolytie effect superior to
free RGDS plus liposomes encapsulated with UK.The results suggest
that modification of liposome with RGDS peptide may potentiate
specific thrombolytic targeting of and therapeutic effect of liposome
encapsulated thrombolytic.
出处
《北京医科大学学报》
CSCD
1994年第3期174-177,共4页
Journal of Peking University(Health Sciences)
关键词
纤维蛋白原
受体
肽
溶栓
心肌梗塞
Fibrinogen receptor
Liposome
RGDS
peptide
Thrombolysis
