摘要
本文报道了对沈阳市高校知识分子人群原发性高血压病1:1配比病例对照研究结果。结果表明原发性高血压病与高血压家族史、超体重、饮酒有关,OR值分别为3.38、2.57、2.74。条件logistic回归模型的多因素分析所得的危险因素与单因素分析相同,最终进入方程的是EHT家族史、体重指数和饮酒。EHT家族史和体重指数两因素间有交互作用。用Falconer法计算遗传度为59.04％,说明遗传因素是EHT的重要危险因素。将AB0血型作为一种遗传标记,研究EHT,EHT组A型基因频率较对照和辽宁省汉族正常人群都有增加。
A case-control study of essential hypertension was car- ried out in Shengang city. An 110 cases with essential hyper- tension were matched with controls. Analysis of single-factor and conditional logistic regression model were used to identify factors which associated with the essential hypertension. The study demonstrated that the family history, overweight and drink were significantly associated with essential hyperten- sion. There were no evidences that smoke, serum cholesterol and triglyceride. According to Falconer method, heritability of essential hypertension was 59. 04% in study.
关键词
高血压
回归模型
遗传度
病因
Essential hypertension Logistic reegression model Heritability
