摘要
目的 :观察芪冬颐心口服液 (QDYX)对正常犬血流动力学和心肌耗氧量的影响 ,及对急性心肌梗死犬的影响。方法 :采用麻醉开胸犬 ,测定心脏血流动力学和心肌氧代谢参数 ,并结扎犬左冠状动脉前降支(L AD)复制急性心肌梗死模型 ,测定心肌梗死面积及血清酶学变化。结果 :1.0、 2 .0 g· kg- 1 QDYX可降低冠脉阻力 ,增加冠脉流量 ,减少心肌耗氧量 ,缩小心肌梗死面积 ,降低血清肌酸激酶 (CK)及乳酸脱氢酶 (L DH)活性。结论 :QDYX能降低冠脉阻力 ,增加冠脉流量 ,减少心肌耗氧量 ,对缺血心肌具有保护作用。
Objective To observe the influences of QiDong YiXin(QDYX) on hemodynamics and myocardial oxygen consumption, and its protective effects on acute myocardial infarction in anesthetic dogs. Methods The parameters of hemodynamics and myocardial oxygen metabolism were measured in the anaesthetic dogs with thoracotomy. The myocardial infarction size and the changes of the enzymes in serum were determined by using the acute myocardial infarction models with ligation of LAD in the anaesthetic dogs with thoracotomy. Results The coronary resistance and myocardial oxygen consumption were decreased, the myocardial blood flow was increased in dogs treated with QDYX of 1.0 and 2.0 mg·kg -1 . The myocardial infarction size and the activities of serum creatine kinase (CK) and lactic dehydrogenase (LDH) were decreased in acute myocardial infarction dogs treated with QDYX of 1.0 and 2.0 mg·kg -1 . Conclusion QDYX has protective effect on myocardial ischemia through decreasing myocardial oxygen consumption in dogs.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2004年第5期738-741,共4页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅资助课题 (94 2 30 1)
