摘要
用荧光光谱研究了1,4-二氢吡啶衍生物(1,4-DHP)与小牛胸腺DNA(CT-DNA)的相互作用。结果表明,1,4-DHP衍生物分子与CT-DNA相互作用后,如其荧光显著增强,表明1,4-DHP衍生物分子嵌入到CT-DNA中,如荧光明显减弱,表明1,4-DHP衍生物分子不是以嵌入模式与CT-DNA相互作用。
The interaction of the 1,4-dihydropyridine derivative(1,4-DHP) with calf thymus DNA(CT-DNA) was studied by using fluorensence spectroscopy.The results indicated that after the 1,4-DHP derivative interacts with CT-DNA,the intensity of the fluorescence peak of the 1,4-DHP derivative is increased,illustrating that the 1,4-DHP derivative is intercalated into CT-DNA.If the intensity of the fluorescence peak of 1,4-DHP derivative is decreased,the interaction between the 1,4-DHP derivative and CT-DNA is not in the intercalation mode.
出处
《南京晓庄学院学报》
2005年第5期45-49,共5页
Journal of Nanjing Xiaozhuang University
基金
江苏省教育厅自然科学基金(批准号:02KJB150006)
国家"211"工程重点学科建设资助项目
