摘要
目的奥沙利铂与氟尿嘧啶、亚叶酸钙联合治疗晚期大肠癌的临床疗效和不良反应。方法应用奥沙利铂与氟尿嘧啶、亚叶酸钙联合治疗晚期大肠癌40例,其中初治19例,复治21例,21天为一个周期,2个周期后评价疗效。结果40例患者中,总有效率为38%.直肠癌18例,PR6例,SD8例,PD4例,有效率为33.3%;22例结肠癌患者中,CR1例,PR9例,SD8例,PD4例,有效率为45.5%。初治患者19例,CR1例,PR7例,有效率为42.1%。复治患者21例,PR8例,有效率为38.1%,毒副反应主要表现为I度的神经毒性和I-II度的消化道反应以及骨髓抑制。结论奥沙利铂与氟尿嘧啶、亚叶酸钙联合治疗晚期大肠癌有效率高,毒副作用可以耐受,值得广泛应用于临床。
Objective To observe the clinical response and toxic reaction of oxaliplatin and 5-FU combined with CF in treatment of patients with advanced colorectal cancer.Methods In forty (40) cases, patients with advanced colorectal cancer were given oxaliplatin and 5-FU combined with CF. It was renewed in a twenty-one day period, to evaluate the effects after two treatments.Results The response rate (PP) was 38%; in 18 cases with patients of rectum cancer, the PP was 33.3%. Not one case got CR, 6 PR, 8 SD, or 4 PD. ...
出处
《安徽医学》
2009年第3期311-312,共2页
Anhui Medical Journal
