摘要
目的了解南京地区近年来结核病耐药的发展趋势。方法对1996—2006年南京市胸科医院肺结核病例采用绝对浓度间接法进行了10种常用抗结核药物的敏感试验并对结果进行分析。结果各年每种抗结核药物的耐药率在一定范围内上下波动,但是耐多药率却是呈现逐步上升趋势,一线抗结核药物的耐药率明显高于二线抗结核药物的耐药率。结论耐多药的发展趋势对目前以INH和RFP为主要抗结核药物的治疗方案构成了巨大的威胁,尽快开发新的低毒高效的抗结核药物是解决目前抗结核治疗困境的当务之急。
Objective To analyze the drug resistance trend of Mycobacterium tuberculosis in Nanjing region. Method Absolute concentration method was used to detect the sensitivity of the 10 most used mycobacterium drugs. Results Resistance rate of each anti-tuberculosis drug fluctuated in some range, while resistance rate to multi-drug increased year by year. The resistant rate to first-line anti-tuberculosis drugs was fairly higher than to second-line anti-tuberculosis drugs. Conclusion The trend of resistance rate ha...
出处
《中国防痨杂志》
CAS
2008年第5期406-408,共3页
Chinese Journal of Antituberculosis
关键词
结核
耐药
南京市
tuberculosis
drug resistance
Nanjing
