摘要
东当归(Angelica acutiloba(Sieb.et Zucc.)Kitagawa)目前在日本、朝鲜等国家及我国朝鲜族自治州均有应用,极具开发潜力与应用价值,笔者通过中国知网、Pubmed等数据库检索东当归的国内外相关研究文献报道,并结合本草组鉴、Pubchem、Chemical book等数据库对东当归的化学成分与药理活性进行归纳总结。迄今分离鉴定得到的东当归化学成分主要为挥发油、香豆素类、有机酸类、黄酮类、多糖类等,由于种植方法与产地的不同,不同产区的成分含量有所区别。东当归的多种成分通过多途径发挥药理活性,如水提物、醇提物及部分单体在循环系统、神经系统、免疫系统等多个系统具有良好的调节作用,主要是改善造血与心血管系统、护肝、抗炎、抗菌、改善学习记忆功能、抗光老化和抗肿瘤等药理活性。本文对近年国内外东当归的化学成分以及药理作用研究进展进行梳理,以期为东当归的药效物质基础研究、药用资源开发及临床应用提供参考。
Angelica acutiloba(Sieb.et Zucc.)Kitagawa(AAK)is applied at Japan,Korea and Chaoxian nationality in China,which conceals exploiting potential and application value.The information of A.acutiloba was summarized base on CNKI and Pubmed databases,combining with Herb,Pubchem,Chemical book databases.Nowadays the compounds of AAK consist of volatile oil,coumarins,flavonoids,polysaccharide and so on.Due to the different planting methods and production areas,the content of compounds varies from region to region.Various of AAK compounds exert pharmacological activity through multiple pathways.It's aqueous extract,alcohol extract and partial monomer play an important role in regulating multiple systems such as the circulatory system,nervous system,and immune system.Those ingredients improve the pharmacological activities of hematopoietic and cardiovascular system,protect liver,combat inflammation,resist bacteria,improve learning and memory function,retard photoaging and resist tumor.In this paper,the progress of chemical constituents and pharmacology activity of AAK were sorted out from recent two decades,so as to offer assistance for therapeutic material basis,development of medicinal resource and clinical utilization.
作者
莫家欣
陈汉坤
韩凌
袁小红
朱伟
Mo Jiaxin;Chen Hankun;Han Ling;Yuan Xiaohong;Zhu Wei(School of the Second Clinical Medical College,Guangzhou University of Chinese Medicine,Guangzhou 510120,China;Qinglan Biotechnological Co.,LTD,Guangzhou 510920,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2023年第9期3153-3163,共11页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
广州市科学技术局市校(院)联合资助项目(202201020296):调脾护心方通过上调GPX4增加易损斑块中M2巨噬细胞对铁死亡耐受性的机制研究,负责人:朱伟。
关键词
东当归
化学成分
苯酞
香豆素
护肝
改善心血管功能
Angelica acutiloba(Sieb.et Zucc.)Kitagawa
Chemical compounds
Phthalide
Coumarins
Protect liver
Improve cardiovascular function
