晚期宫颈癌患者以白蛋白结合型紫杉醇治疗的临床疗效观察被引量：6

导出

摘要目的探讨白蛋白结合型紫杉醇治疗晚期宫颈癌的效果。方法选取晚期宫颈癌患者50例,按照随机数字表法,分为对照组和观察组,各25例。对照组采用紫杉醇进行治疗,观察组采用白蛋白型紫杉醇进行治疗,比较两组治疗效果和不良反应发生情况。结果观察组治疗总有效率高于对照组,差异具有统计学意义(P<0.05);观察组治疗后瘤体最大径小于对照组,症状缓解时间短于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论白蛋白型紫杉醇治疗晚期宫颈癌的疗效优于紫杉醇,有利于临床症状的缓解,且药物副作用更低。

作者闫彩霞罗路平

机构地区河南科技大学第一附属医院

出处《首都食品与医药》 2020年第3期70-71,共2页 Capital Food Medicine

关键词晚期宫颈癌白蛋白型紫杉醇紫杉醇疗效

分类号 R737.33 [医药卫生—肿瘤]

引文网络
相关文献

参考文献6

1冯涛.卡前列素氨丁三醇联合垂体后叶素治疗产后出血的效果、安全性及对凝血功能的影响[J].中国现代药物应用,2019,13(5):124-126. 被引量：6
2陈汉华,吕宇.白蛋白结合型紫杉醇新辅助化疗对宫颈癌患者术后疗效影响的研究[J].癌症进展,2017,15(3):259-261. 被引量：9
3肖群,方燕飞,孔于兰.同步放化疗与单纯放疗对中晚期宫颈癌患者的有效性及安全性比较[J].中华全科医学,2018,16(11):1813-1815. 被引量：21
4周晖,刘昀昀,林仲秋.《2017 NCCN宫颈癌临床实践指南》解读[J].中国实用妇科与产科杂志,2017,33(1):100-107. 被引量：98
5庄晴晴,王常玉.新辅助化疗与单纯手术在局部晚期宫颈癌患者中的疗效对比分析[J].现代妇产科进展,2016,25(7):487-490. 被引量：48
6李凤虎,杨飞月,常建英,鲁亮,曾继泽,李杰慧,陈燕平,王鹤然,吴莉,冉立,李杭.宫颈癌紫杉醇联合洛铂或顺铂新辅助序贯洛铂或顺铂同步化放疗多中心随机临床研究[J].中华肿瘤防治杂志,2016,23(16):1090-1094. 被引量：37

二级参考文献46

1Fu JH, Gao Z, Ren CC, et al. Comparison of clinical efficacy of three different neoadjuvant approaches (chemotherapy combined vaginal intraeavitary irradiation, neoadjuvant chemotherapy alone or radiotherapy) combined with surgery for patients with stage I b2 and II a2 Cervical Cancer[J]. Asian Pac J Cancer Prey, 2013,14(4) .. 2377-2381. 被引量：1
2Li Z, Yang S,Liu L, et al. A comparison of concurrent chemora- dio-therapy and radiotherapy in Chinese patients with locally ad- vanced cervical carcinoma., a multi-center study[J]. Radiat On- col,2014,9(6) ..212-216. 被引量：1
3Roberto A, Francesco P, Alessia A, et al. A randomized controlled trial comparing four versus six courses of adjuvant platinum-based chemotherapy in locally advanced cervical cancer patients previously treatedwoth neo-adjuvant chemotherapy plus radical surgery[J]. Gy- necol Oncol, 2015,139(24) : 433-438. 被引量：1
4Sardi J,Sananes C,Giaroli A, et al. Results of a prospective ran- domized trial with neoadjuvant chemotherapy in stage I B,bulk- y, squamous carcinoma of the cervix[J]. Gynecol Oneol, 1993,49 (2) :156-165. 被引量：1
5Rose PG. Combined-modality therapy of locally advanced cervi- cal cancer[J]. J Clin Oncol,2003,21(10):211-217. 被引量：1
6Angioli R,Plotti F,Luvero D,et al. Feasibility and safety of car- boplatin plus paclitaxel as neoadjuvant chemotherapy for locally advanced cervical cancer:A pilot study[J]. Tumour Biol, 2013, 11(3) :15-19. 被引量：1
7Singh U,Ahirwar N,Rani AK,et al. The efficacy and safety of neoadjuvant chemotherapy in treatment of locally advanced carci- noma cervix[J]. J Obstet Gynecol India, 2013,63 (4) : 273-278. 被引量：1
8Emily SW, Titilope O, Lauren PC, et al. Lymphopenia and its association with survival in patients with locally advanced cervi- cal cancer[J]. Gynecol Oncol, 2016,140(31) .. 76-82. 被引量：1
9Yang ZJ, Chen DD, Zhang JQ, et al. The efficacy and safety of neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer: A randomized multicenter study [J]. Gynecol Oncol, 2016,141(10) : 231-239. 被引量：1
10Angioli R,Plotti F,Aloisi A,et al. A randomized controlled trial comparing four versus six courses of adjuvant platinum-based chemotherapy in locally advanced cervical cancer patients previ- ously treatedwith neo-adjuvant chemotherapy plus radical sur- gery[J]. Gynecologic Oneol, 2015,139 (82) : 433-438. 被引量：1